Novel treatment approach of peritoneal carcinosis using Vaccinia virotherapeutics

Introduction: Two of the most frequent cancer species worldwide are colorectal and ovarian cancer often spreading into the peritoneal cavity. So far, there is no standard curative therapy available for peritoneal carcinosis. A novel strategy to kill all cancer cells within the peritoneal cavity could be the use of a virotherapeutic combined with the surgical method of peritonectomy. JX-594, an oncolytic poxvirus, already has demonstrated antitumoral activities in patients with primary or metastatic liver cancer. Furthermore, the oncolytic Vaccinia virus GLV-1h68 already revealed its ability to reduce the cell ma…