Expressionsmuster von CD 34 und glattmuskulärem Aktin (SMA) als Indikatoren für das peritumorale Stromaremodelling beim Zervixkarzinom

Fragestellung: CD 34 staining has been reported in normal endocervical stroma and its loss as an indicator for peritumoral stromal remodelling in case of invasive cancer. CD 34 loss might be associated with upregulation of smooth muscle actin (SMA). The present study evaluates CD 34 and SMA expression within peritumoral stromal cells in squamous cell carcinoma of the uterine cervix (CX). Methode: CD 34 and SMA immunohistochemistry was performed on samples of 103 surgically treated CX. Staining results were scored as negative/low (50% stroma positive). Staining results were compared to different patterns of invas…