Fatty acid synthase (FAS-272) expression increases with rise of WHO-grade and serves as indicator for the malignant transformation in human gliomas.

Purpose: Gliomas are highly invasive neuroepithelial tumors with a propensity of malignant transformation and still restricted treatment options. Fatty acid synthase is a cytosolic multifunctional polypeptid which plays an essential role in cell metabolism. It catalyses the conversion of dietary carbohydrates to fatty acids which are incorporated as phospholipids into the cell membrane. High expression levels of fatty acid synthase (FAS) have been reported in hormone receptor-positive tumors. In our current study we investigate the expression of FAS in gliomas of different WHO-grades as a possible new target for…