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Epigenetic deregulation of the dopamine receptor D4 in pediatric brain tumors

R Unland, S Schlosser, J Mühlisch, MC Frühwald · Klinische Pädiatrie · 2011 · Heft 11

Dokument
1048961
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
R Unland, S Schlosser, J Mühlisch, MC Frühwald
Ausgabe
Heft 11 / 2011
Seiten
–
Erschienen: 2011-11-03 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0031-1292595

Zusammenfassung

Epigeneitc alterations such as DNA methylation and histone modifications are common events in cancer. DNA methylation of promotor associated CpG islands constitutes an additional oncogenic mechanism in tumor development inducing among others inactivation of tumor suppressor genes. To discover novel methylation targets in pediatric brain tumors, genome wide methylation analysis was performed. AscI-RLGS of CNS tumors and non-malignant controls identified the dopamine receptor D4 (DRD4) as a novel methylation target. Tumor-specific methylation of DRD4 of >35% was deteced in 18/24 medulloblastomas, 23/29 ependymomas…

Schlagworte

Klinische Pädiatrie