Does preimplantation genetic diagnosis (PGD) reduce risk of adverse reproductive outcomes in balanced chromosome translocations' (BCTs) carriers?
N Andronova, NV Zaretskaya, O Doronina, O Bykovskaya, E Yutkin, A Solodovnikov, S Yakovenko · Geburtshilfe und Frauenheilkunde · 2011 · Heft 11
Bibliografische Angaben
Zusammenfassung
BCTs' carriers are at higher risk for infertility, recurrent miscarriage, birth of a phenotypically abnormal child due to high rate of abnormal gametes and embryos [Ozawa N., 2008, Speicher M.R., Antonarakis S.E., Motulsky A.G., 2010]. PGD allows selection and transfer in utero chromosomally balanced embryos [Verlinsky Y., 1996]. However, in light of contradictory results of studies examining PGD effectiveness [Fischer J., 2010, Franssen M.T., 2011, Mastenbroek S, 2011] it is still unclear whether PGD is associated with substantial reduction in adverse reproductive outcomes in BCTs' carriers. The aim of this coh…
