JNK1 is protective for the progression of NEMO-dependent hepatitis
FJ Cubero, G Zhao, M Hatting, O Drvarov, Y Nevzorova, M Al Massoudi, N Gassler, C Liedtke, C Trautwein · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Deletion of the regulatory subunit IKKγ/NEMO of NF-κB in hepatocytes (NEMOΔhepa) triggers chronic inflammation and spontaneous hepatocellular carcinoma (HCC). We have previously reported that JNK in NEMOΔhepa mice is chronically activated which suggests that the JNK signaling pathway is essential in the progression of the disease. Aims: to elucidate the role of JNK1 and JNK2 in the development of hepatitis, steatosis, fibrosis and tumor development proliferation in a spontaneous model of liver injury. Methods: we generated NemoΔhepa/JNK1-/- and NemoΔhepa/JNK2-/- and their respective controls and characteri…
