In vitro and in vivo models for chemotherapy-associated steatohepatitis reveal an effect of irinotecan on fatty acid binding protein expression

Preoperative chemotherapy with irinotecan is associated with the development of chemotherapy-associated steatohepatitis (CASH). This increases the risk of perioperative morbidity and mortality, however, the underlying mechanisms of irinotecan induced hepatic steatosis and inflammation are still unknown.The aim of this study was to establish in vitro and in vivo models of irinotecan induced CASH and to unravel the molecular mechanisms of this phenomenon. Methods and Results: Initially, we determined the dose-range in which irinotecan treatment did not affect the viability of hepatoma cells and primary human hepat…