MSCs augment liver regeneration after paracetamol-induced acute liver injury by their anti-apoptotic and pro-proliferative mode of action

Paracetamol (acetaminophen) intoxication is the most common cause of acute liver failure, consequently liver transplantation is acquired.Because there is a deficit of donor organs, new feasible therapeutic approaches are necessary.Thus, the aim of the study was to establish a rat model of acetaminophen intoxication and to proof the potential of mesenchymal stem cells (MSCs) to promote liver regeneration after this toxic challenge.In 7 weeks old F344 (DPPIV-/-) Fischer rats acute liver failure was induced by 3 oral doses of 4g/kg bw acetaminophen. 6h after the final dose MSCs were administered systemically by tai…