MHC class I transfer from stellate cells to LSEC allows for sinusoidal immunsurveillance

The liver is known for its unique immunological properties. Besides liver parenchymal cells, the hepatocytes, also non-parenchymal cells like dendritic cells, liver-resident macrophages, the Kupffer cells, and liver sinusoidal endothelial cells (LSEC) participate in interaction and modulation of passenger leukocytes. However, little is known on the contribution of stellate cells, non-parenchymal liver cells responsible for contraction of vessel diameter and storage of vitamin A. Because of their location in the space of Dissé stellate cells have no direct contact to circulating lymphocytes.Here we addressed the…