Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome
B Goeppert, L Frauenschuh, M Zucknick, A Stenzinger, A Mehrabi, M Hafezi, A Warth, A Thelen, M Bahra, B Sinn, D Seehofer, P Neuhaus, P Schirmacher, W Weichert · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Cholangiocarcinoma (CC) is a rare malignant tumor arising from bile duct cells. The prognosis of affected patients is poor. Several risk factors including cholangiolithiasis, liver fluke infection, and anatomical abnormalities, all associated with inflammation of the biliary tract, have been described. In addition, tumor-infiltrating immune cells (TIC) as well as expression of antigen presenting molecules are known to correlate with patient survival in several tumor entities. Therefore, we aimed to characterize the expression of major histocompatibility complex class I (MHC I) and TIC in a large cohort of CC (n=…
