Adsorption of model proteins and physiologically most relevant SP-A to metal oxide nanoparticles

Einleitung: Engineered metal oxide nanoparticles are produced at tons scale already. Since the miniaturization of materials into the nano-size range may dramatically change physical and chemical properties, nanomaterials will obviously also interact in a different way with biological systems. Once they entered the body, the can interact with the physiological surroundings, i.e. also with proteins. This particle-protein interaction might lead to altered reactions, hence, the investigation of protein adsorption to those particles is of great importance. Methoden: We quantified and compared the protein adsorption o…