Airway dendritic cell behaviour is influenced by neuropeptide release from sensory nerves

The airway mucosal epithelium permanently faces airborne particles. A network of immune cells patrols at this frontier to the environmental surface. The interplay of immune cells is orchestrated by different mediators. In the current study we questioned whether neuropeptides can alter key features of DC as there are movement behavior and phagocytosis capacity. With a two-photon microscopic time-lapse analysis of DC in the airways of ex vivo vital lung sections of CD11c-EYFP transgenic mice we focused on the influence of neuropeptides on dendritic cells (DC). Additionally, with a confocal microscopic approach and…