4–12 Hz oscillatory activity is suppressed during deep brain stimulation in patients with phasic dystonia

Aims: Enhanced low frequency (4–12 Hz) activity is found in pallidal local field potential (LFP) recordings in patients with dystonia and has been related mainly to phasic involuntary movements. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) may suppress pathological synchronized activity leading to improvement of motor symptoms. Here, we investigate changes in 4–12 Hz oscillatory activity during DBS in patients with dystonia. Methods: LFPs were recorded from DBS electrodes implanted in 10 GPi of 9 dystonia patients using a specially designed amplifier, allowing simultaneous stimulation and r…