Treatment of the schizoaffective psychosis according to a neuronal network

Introduction: In schizoaffective psychosis exists a GABA and glutamate deficiency leading to dopamine and serotonin hyperactivity in the mesolimbic system. In mania there is noradrenaline and dopamine hyperactivity in the hippocampus and in depression monamine deficiency in the hippocampus and the midbrain. Material/Methods: In the mesolimbic system dopaminergic neurons transmit a strong activating impulse via D2 receptors to glutaminergic neurons which weakly inhibit the serotonergic neurons via NMDA receptors. The latter neurons transmit a strong activating impulse via 5-HT2A receptors to GABAergic neurons whi…