Ventilator-induced lung injury in severe pneumococcal pneumonia: protection by Adrenomedullin
HC Müller-Redetzky, D Will, K Hellwig, W Kummer, T Tschernig, U Pfeil, R Paddenberg, S Hippenstiel, N Suttorp, M Witzenrath · Pneumologie · 2012 · Heft 02
Bibliografische Angaben
Zusammenfassung
Ventilator-induced lung injury (VILI) contributes to mortality in ARDS. Particularly preinjured lungs may be susceptible to VILI despite lung protective ventilation. We previously observed protection against VILI by therapeutic use of the endogenous peptide Adrenomedullin (AM) in addition to lung protective ventilation in mice. The current study analyzed the impact of mechanical ventilation (MV) on lung injury, pulmonary and systemic inflammation and bacterial burden in established pneumonia. Further, AM was used therapeutically to limit VILI in a clinically relevant murine model. S. pneumoniae infected individu…
