Stress pathways controlling HNSCC dormancy are differenzially regulated in pediatric ALL cell lines

Introduction: In pediatric ALL, achieving complete remission shortly after therapy initiation isprognostic, but little is known on dormancy of leukemic cells surviving chemotherapy in the bone marrow (BM) niche. InHNSCC, dormancy is maintained by MAPK-dependent regulation of stress pathways in the ER. Mediators of ER-stress orchestrate a cellular response characterized by growth arrest and survival upon chemotherapeutic or microenvironmental stress. Method: In vitro studies to elucidate mechanisms mediating ALL dormancy in the BM microenvironment. Results: TEL-AML1 positive REH cells display a dormancy signature…