CYP24A1 and CYP27B1 MRNA expression in human hepatocellular carcinoma
E Horvath, PA Lakatos, B Balla, JP Kósa, B Tóbiás, Á Somorácz, H Jozilan, L Harsányi, P Kupcsulik, Z Schaff, F Szalay · Zeitschrift für Gastroenterologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background and Aims: The discovery of the anti-tumor effect of 1,25-dihydroxyvitamin D3 (1,25-D3) on various malignancies, including hepatocellular carcinoma (HCC), suggested that a new treatment opportunity may exist. The use of 1,25-D3 analogs without hypercalcemic effects is the subject of preclinical and clinical studies. Increased activity of 24-hydroxylase (CYP24A1), the key enzyme neutralizing of 1,25-D3, has been found in colon, lung, prostate, thyroid, breast, and ovarian cancer cells. In a previous study we found increased CYP24A1 mRNA expression following 1,25-D3 administration in HCC cell lines in vi…
