Presence of class IGA anti-neutrophil cytoplasmic antibodies (ANCA) in cirrhosis – A tell-tale sign of compromised mucosal immunity?
M Papp, I Foldi, Z Vitalis, I Altorjay, I Tornai, M Udvardy, K Fechner, P Lakatos, J Kappelmayer, P Antal-Szalmas · Zeitschrift für Gastroenterologie · 2012 · Heft 05
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Zusammenfassung
Background& Aims: Anti-neutrophil cytoplasmic antibodies (ANCA) are a non-uniform family of antibodies recognizing divers constituents of neutrophil granulocytes. ANCA formation might be induced by protracted bacterial infections or probably reflect an abnormal immune response to intestinal microorganisms. Bacterial infections are common complications in cirrhosis with high incidence of episodes caused by enteric organisms. Methods: Sera of 385 patients with cirrhosis of different etiologies were assayed for IgA and IgG class ANCA by indirect immunofluorescence. Control group comprised 202 patients with chronic…
