CareLit Fachartikel

CD74 indicates microglial activation in a rat model of diabetic retinopathy

J Wang, J Lin, L Wu, S Busch, W Kanyanat, HP Hammes · Diabetologie und Stoffwechsel · 2012 · Heft 05

Dokument
1049677
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
J Wang, J Lin, L Wu, S Busch, W Kanyanat, HP Hammes
Ausgabe
Heft 05 / 2012
Seiten
–
Erschienen: 2012-05-08 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0032-1314435

Zusammenfassung

Introduction: Diabetic retinopathy induces vasoregression and is associated with microglial activation. Our published data indicate that CD74+ microglia is associated with vasoregression secondary to neurodegeneraton in the non-hyperglycemic polycystic kidney disease (PKD) rat model. CD74, the MHC class II invariant chain, elicits local proinflammatory responses. In this study, we investigated expression of CD74 in microglia in a rat model of diabetic retinopathy. Methods: Streptozotocin (STZ; 43mg/kg body weight i.v.)-induced diabetic female Sprague Dawley rats were used. Retinal whole-mount immunofluorescence…

Schlagworte

Diabetologie und Stoffwechsel