Effects of Insulin Degrading Enzyme (IDE)-activity on the liver cancer cell transcriptome
O Pivovarova, I Ilkavets, S Zhuk, A Malashicheva, A Kostareva, S Dooley, AFH Pfeiffer, N Rudovich · Diabetologie und Stoffwechsel · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: Type 2 diabetes mellitus (T2DM) characterized by hyperinsulinemia is an independent risk factor for development and progression of hepatocellular carcinoma. Insulin degrading enzyme (IDE) is a major enzyme responsible for insulin degradation. We and others demonstrated that metabolic modulation of IDE activity is more important for its overall action than alterations of its protein level. Inhibition of IDE activity results in increased intracellular insulin concentration, which is probably crucial for insulin-dependent regulation of gene expression and cell proliferation. Therefore, modulating IDE activity…
