Effects of Liraglutide on Caenorhabditis elegans

Aims: C. elegans was used as a model organism to study effects of glucagon-like peptide-1 (GLP-1) analogue liraglutide, which is known to have neuroprotective effects, on glucose driven changes of lifespan and neuronal function. The short lifespan, good accessibility and strong homologies between human and C. elegans insulin signal transduction system offers excellent opportunities to study molecular mechanisms being responsible for these changes. In C. elegans, high glucose conditions impair neuronal function and reduce lifespan, likely driven by formation of advanced glycation end products (AGEs). In addition,…