Distribution and efficacy of a GATA-3-specific DNAzyme in experimental allergic asthma models

Allergic bronchial asthma is a chronic inflammatory disease of the airways. T helper 2 (Th2) cells and their master transcription factor GATA-3 that controls differentiation and effector function of these cells, have been shown to play a central role in the pathology of the disease. Except Th2 cells, GATA-3 is also involved in the regulation of other cells contributing to disease development including mast cells, eosinophils and epithelial cells. We developed GATA-3-specific DNAzyme termed hgd40 that combines the high specificity of antisense molecules with an inherent RNA- cleaving enzymatic activity. Intranasa…