Identification of p53 accumulation, EGFR gain and PDGFRα gain/amplification as adverse prognostic factors in pediatric high grade gliomas – evaluation of 48 cases of the German HI…

In adult high grade gliomas (HGG) genetic markers with prognostic/predictive impact including IDH1/2 mutation and MGMT promoter hypermethylation were identified. In contrast, the significance of these key markers remains still unclear in pediatric HGG which are considered to differ from adult HGG in their pathogenesis and biological behaviour. To investigate the frequency and prognostic impact of genetic alterations in a homogenously treated patient cohort, we analysed 70 consecutive cases enrolled into the multicenter HIT-HGG trials; in 48 cases, formalin-fixed, paraffin embedded material was available for DNA…