Membrane vs. cytoplasmatic staining for TRAIL-receptors in colorectal cancer: prognostic significance and therapeutic pitfalls
L Kriegl, A Jung, D Horst, R Jackstadt, H Hermeking, E Gallmeier, AL Gerbes, T Kirchner, B Göke, EN De Toni · Zeitschrift für Gastroenterologie · 2012 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background: The fact that the receptors for the TNF-related apoptosis inducing ligand (TRAIL) are almost invariably expressed in colorectal cancer samples represents the rationale for the development of several agonistic antibodies targeting TRAIL-R1 and TRAIL-R2 for the therapy of colorectal cancer (CRC) patients. However, while the prognostic meaning of TRAIL-R staining in CRC is controversial, first reports on the use of these compounds provided disappointing results. Aim and Methods: We hypothesized that loss of membrane-bound TRAIL-R could be a feature of CRC possibly limiting the efficacy of TRAIL-R target…
