FUT2 and FUT3 depending cut-off values in PSC-patients increase diagnostic accuracy of CA19–9 for detection of biliary malignancies
A Wannhoff, T Folseraas, JR Hov, KH Weiss, W Stremmel, TH Karlsen, D Gotthardt · Zeitschrift für Gastroenterologie · 2012 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: Patients with primary sclerosing cholangitis (PSC) are at increased risk of developing biliary malignancies as cholangiocellular carcinoma (CCA) or gall bladder carcinoma (GBCA). Ultrasound and CA19–9 are the most commonly use screening parameters. FUT2- and FUT3-gene status influences CA19–9 levels. Aims: To evaluate CA19–9 as a diagnostic marker for detecting CCA and GBCA in PSC-patients, depending on the individual's FUT2- and FUT3-gene status. Methods: In 407 PSC-patients, among which 34 (6.9%) had CCA and 3 (0.6%) had GBCA, CA19–9 values were retrospectively analyzed. Depending on the FUT2- an…
