Exosomes – From Bench to Bedside

Based on their proposed broad multi-lineage differentiation potential mesenchymal stem cells (MSCs) became one of the most intensively studied adult stem cell entities within the last 15 years. Up to now, more than 260 different studies have addressed potential therapeutic impacts of clinically administered MSCs in a variety of clinical settings including treatment of graft-versus-host disease (GvHD), acute myocardial infarction, stroke and acute kidney failure (http://clinicaltrials.gov). Several studies showed that the vast majority of intravenously administered MSCs get rapidly trapped in the lung and are rar…