No evidence for increased intestinal permeability in cirrhosis

Background: Alterations in intestinal permeability in patients with liver cirrhosis (LC) have been implicated as an important factor for bacterial translocation (BT), leading to various complications, like spontaneous bacterial peritonitis (SBP). Aim: To evaluate the intestinal permeability to macromolecules in patients with liver cirrhosis as compared to healthy controls and determine their significance in relation with the disease severity (MELD Score). Methods: Polyethylene glycol has been used to measure intestinal permeability. The permeability to polyethylene glycol Mr 400 and Mr 1000 were measured in 10 p…