Global alterations of DNA methylation patterns in cholangiocarcinoma target cancer relevant pathways including Wnt/β-catenin signaling
B Goeppert, C Konermann, C Schmid, O Bogatyrova, L Geiselhart, D Weichenhahn, N Becker, A Mehrabi, M Hafezi, F Klauschen, A Stenzinger, M Renner, A Warth, L Gu, M Zucknick, W Weichert, P Schirmacher, C Plass · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and Aims: The molecular mechanisms underlying the genesis of cholangiocarcinomas (CCs) are poorly understood. Epigenomic changes such as aberrant hypermethylation and subsequent atypical gene expression are characteristic features of most human cancers. In CC, data of global methylation changes are scarce. Methods: We performed a genome-wide analysis for aberrant promoter methylation in human CCs. We profiled ten intrahepatic (ICC) and eight extrahepatic (ECC) CCs, as well as corresponding and non-corresponding non-tumorous biliary tissue specimens using the methyl-CpG immunoprecipitation (MCIp) techn…
