Augmenter of Liver Regeneration has a potential role in tumour resistance in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and the fourth leading cause of cancer-related death worldwide. In most cases, HCC is only diagnosed at a later stage when surgical resection is no longer feasible and the only treatment possible is chemotherapy. Although chemotherapeutical agents are widely used in the attempt to treat HCC, new approaches need to be considered as tumours can be resistant to chemotherapy. A key protein in liver regeneration known as the Augmenter of Liver Regeneration (ALR) is known to be highly expressed in certain forms of HCC and previous investigation…