NKT cell activation influences hepatic immunity by interfering with cross-presentation in liver sinusoidal endothelial cells
L Diehl, JP Böttcher, N von Oppen, C Metzger, S Hegenbarth, G Wingender, C Kurts, B Höchst, D Wohlleber, PA Knolle · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Natural Killer T (NKT) cells are a predominant lymphoid cell population in the liver. They are specifically recruited to the liver via CXCR6 and migrate through the liver sinusoids along liver sinusoidal endothelial cells (LSEC). We have previously shown that LSEC can cross-present soluble antigens on MHC I molecules to CD8 T cells causing a functionally inert state. We now show that LSEC express CD1d and can present the model antigen α-galactosyl-ceramide (αGC) to NKT cells, leading to CD1-restricted NKT cell activation and cytokine production. CD1-restricted NKT activation in vivo led to reduced cross-presenta…
