Reduced threshold for induction of LTP by phasic activation of dopamine D1/D5 receptors at hippocampal CA1-subiculum synapses

Introduction: The phasic release of dopamine in the hippocampal formation has been shown to facilitate the encoding of novel information. There is evidence that the subiculum operates as a detector and distributor of sensory information which incorporates the novelty and relevance of signals received from CA1. The subiculum acts as the final hippocampal relay station for outgoing information. Subicular pyramidal cells have been classified as regular- and burst-spiking neurons. The goal of the present study was to study the effect of dopamine D1/D5-receptor activation on synaptic transmission and long-term potent…