A red vine leaf extract reduces leg swelling in healthy women in a placebo-controlled clinical trial

In the present study, we investigated whether oral intake of a hydroalcoholic extract from red vine leaf (Vitis vinif. fol extra. s. sicc.) extract improves swelling of lower limbs in a single-blinded, placebo-controlled clinical study conducted in Japan using the crossover design. Seventeen healthy women, recurring suffering from swollen legs participated in the trial. Participants ingested 600 mg daily of the extract during 6 weeks, then matching placebo capsules for the same duration after a wash-out period of 2 months. Limb volume was determined by water displacement volumetry at the beginning and at the end…