Neuroprotective effects of Cimicifuga racemosa may be able to prevent age-related neurodegeneration

Age-related estrogen decline affects the aging process of the women brain and is accompanied by a progressive deterioration in cognition, attention, memory, emotional and behavioral state. The impact of menopause-induced complaints in women life is relevant since quality of life and work ability could be markedly affected. The aim of these investigations was to clarify whether the isopropanolic extract of Cimicifuga racemosa rhizoma (iCR) is able to affect brain function. Changes in the expression of c-fos protein (marker of neuronal activity) in the hypothalamic nuclei were investigated in 4 groups of SD rat: S…