Effects of Liraglutide on glucose-induced neuronal damage in Ceanorhabditis elegans

Aims/hypothesis: Ceanorhabditis elegans (C. elegans) was used as a model organism to study effects of the glucagon-like peptide-1 (GLP-1) analogue liraglutide, which is known to have neuroprotective effects. Experimental hyperglycemia caused neuronal dysfunction in C. elegans and reduced lifespan by increased reactive oxygen species (ROS) formation. Liraglutide enhanced the reduced lifespan and showed neuroprotective effects under high glucose conditions. These effects correlated with a reduction of ROS formation. In C. elegans, a key regulator for development, longevity and stress response is DAF-16/FOXO regula…