Loss of function of Ifi202b in C57BL/6J mice suppresses 11β-hydroxysteroid dehydrogenase type 1 expression and development of obesity

Aims: Obesity-associated inflammation of adipose tissue is considered to play a role in the pathogenesis of insulin resistance and type 2 diabetes. Increased production of pro-inflammatory cytokines from hypertrophic adipocytes and the accumulation of macrophages are possible factors linking obesity to insulin resistance. In an outcross population of the New Zealand Obese (NZO) mouse, a polygenic model of obesity and type 2 diabetes, with the lean and diabetes-resistant C57BL/6J (B6) strain, we identified a major quantitative trait locus (QTL) for obesity and hyperglycemia (Nob3) on distal mouse chromosome 1. By…