Identification of germline polymorphisms associated with clinical and toxicity phenotypes in childhood acute lymphoblastic leukemia
T Bartram, E Ellinghaus, R Houlston, M Zimmermann, A Möricke, G Cario, A Franke, M Schrappe, M Stanulla · Klinische Pädiatrie · 2013 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: There are many known undesirable side effects during childhood acute lymphoblastic leukemia (ALL) therapy. However, the reasons why some patients suffer from toxicities and others do not remains to be elucidated. Methods: Genome-wide association analyses of 1,048,683 single nucleotide polymorphisms (SNPs) were conducted in 1489 childhood ALL patients treated on protocol ALL-BFM 2000. Several variables including treatment response and toxicity phenotypes were analyzed. Results: We were able to detect SNPs with highly significant differences regarding several phenotypes. Many of these are on or close t…
