IP-10 and IL-6 as biomarkers in Chronic Thromboembolic Pulmonary Hypertension
D Zabini, Z Bálint, C Nagarai, V Foris, G Kwapiszewska, A Heinemann, P Nierlich, I Lang, W Klepetko, H Olschewski, A Olschewski · Pneumologie · 2013 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: CTEPH is a progressive occlusive pulmonary vascular disease, where inflammatory factors, vascular remodelling and endothelial dysfunction contribute to major and small vessel obliteration. In CTEPH inflammatory factors such as C-reactive protein, tumor necrosis factor-alpha and MCP-1 have been found to be elevated. The correlation of these factors with hemodynamic parameters indicates the important role of inflammation in the progression of the disease. In our study, we have investigated IL-8, IL-6, MCP-1, IP-10, MIG, Rantes, CX3CL1, MIP1alpha, CXCL12 and HMGB1 at three different levels (pulmonary en…
