Increased gut permeability, elevated endotoxin related products and neutrophil dysfunction in liver cirrhosis
A Horvath, B Leber, S Lemesch, P Stiegler, R Stauber, P Fickert, G Zollner, W Spindelböck, E Krones, F Durchschein, P Douschan, V Stadlbauer-Köllner · Zeitschrift für Gastroenterologie · 2013 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: Infection is the most common precipitant for decompensation in liver cirrhosis. Endotoxin can enter the circulation due to increased gut permeability, and contributes to inadequate activation and dysfunction of the innate immune system in alcoholic cirrhosis. The aim of the study was to assess gut permeability, presence of endotoxin and neutrophil function in patients with liver cirrhosis. Methods: 40 patients with liver cirrhosis (24 alcoholic, 16 non-alcoholic) and 8 healthy controls were studied. Gut permeability was assessed by differential sugar absorption and determination of diaminooxidase (…
