Differential expression of trophoblast-, endothelial- and embryonic-stem-cell-associated transcription factors in 1st trimester, and 3 rd trimester preeclampsia (PE), intrauterine…

Objectives: Stem cells are highly proliferative, undifferentiated cells and stem cell-associated markers (SCM) are involved in maintaining these characteristics. Trophoblast progenitor cells are known to express these markers, and are cells which replenish the outer syncytiotrophoblast layer when necessary. Little data is available characterizing the expression of SCMs beyond the blastocyst stage or during pregnancy pathologies. We aimed to describe the expression of trophoblast and other SCMs in the placenta of 1st and 3rd trimester, but also of preeclampsia (PE) and intrauterine growth retardation (IUGR) pregn…