CareLit Fachartikel
Overexpression of IL-9 and its receptor by leukocytes contributes to the pathogenesis of ulcerative colitis
MT Chiriac, N Nalleweg, G Hundorfean, MF Neurath, J Mudter · Zeitschrift für Gastroenterologie · 2013 · Heft 08
Dokument
1051270
CareLit-ID
Jahr
2013
Publikation
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Metadaten
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Zusammenfassung
Introduction: IL-9 and its receptor have been historically linked to the pathogenesis of asthma. More recently, a subpopulation of lymphocytes so called Th9 cells were identified to produce large amounts of IL-9. However, the role of this cytokine and its receptor in ulcerative colitis, a disease characterized by high granulocyte accumulation resulting in crypt abscess, has not been addressed so far. Methods: The capacity of peripheral blood lymphocytes to produce IL-9 upon stimulation with anti-CD3/anti-CD28 has been investigated by ELISA whereas the expression of the IL-9 receptor by peripheral blood cells was…
Schlagworte
Blood
Blood Cells
C-Reactive Protein
Cytokine
Abscess
Asthma
Zeitschrift für Gastroenterologie
