Decreased TRAIL expression is a dominant feature of human HCC
K Straub, F Weber, K Khairzada, F Simon, M Trippler, A Paul, G Gerken, K Herzer · Zeitschrift für Gastroenterologie · 2013 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: The proapoptotic molecule TRAIL has gained attention for its ability to induce apoptosis in liver cancer cells without damaging normal liver cells. It may play an important role in preventing development and outgrowth of liver tumors. HCC is recognized as one of the most common and most malignant cancers worldwide. However, the molecular mechanisms causing the sequence of events of its development are still poorly understood. To clarify the clinical implication of TRAIL for HCC development, the expression of TRAIL was analysed in a large series of human HCCs. Methods: 70 patients undergoing partial liver r…
