Rat model of fractionated (2 Gy/day) 60 Gy irradiation of the liver: long-term effects
M Rave-Fränk, I Malik, H Christiansen, S Sultan, N Naz, A Amanzada, S Ahmad, CF Hess, F Moriconi · Zeitschrift für Gastroenterologie · 2013 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: Radiotherapy of liver tumors is limited by supposed sensitivity of liver tissue possibly leading to radiation-induced-liver disease. However in rats, high single dose irradiation (HDI) showed only mild effects. Consequences of fractionated irradiation (FI) in such an animal model have not been studied. Materials and methods: Rats were exposed to selective liver FI (total dose 60 Gy, 2 Gy/day) or HDI (25 Gy) and were sacrificed after three-months or additionally after 1 to 48h (HDI, only). Blood cells, serum, and livers of the animals were preserved. Tissue samples were used for immunohistochemical…
