Xanthohumol inhibits the development of non-alcoholic steatohepatitis by systemic as well as direct effects on hepatocellular lipid uptake
C Dorn, A Mahli, WE Thasler, M Müller, C Hellerbrand · Zeitschrift für Gastroenterologie · 2013 · Heft 08
Bibliografische Angaben
Zusammenfassung
There is growing interest in phenolic compounds and their presumed role in the prevention of various degenerative diseases. Xanthohumol, the principal prenylated flavonoid of the female inflorescences of the hop plant, has been most extensively studied as cancer chemopreventive agent. In addition, anti-inflammatory properties have been demonstrated in various organs including the liver. Nonalcoholic fatty liver disease (NAFLD) is considered as hepatic manifestation of the metabolic syndrome, and in a subset of cases hepatic steatosis progresses to steatohepatitis (NASH), which may further advance with significan…