The role of insulin receptor and insulin-like growth factor I receptor in pancreatic ductal adenocarcinoma

Aims: PDAC ist the fourth leading cause of malignancy related deaths in humans due mainly to the lack of effective therapies. Insulin and Insulin-like growth factors and their receptors (IR and IGF1R) have been acknowledged as important players in a variety of cancers. The aim of this study is to investigate the role of IR and IGF1R in PDAC initiation and progression. Methods: Multiple genetically engineered mouse models (GEMM) targeting oncogenic and tumor suppressive genes combined with pancreas-specific deletion of IGF1R and IR were generated and characterized. Various molecular and metabolic analyses were us…