CareLit Fachartikel
Is MGMT inducible in malignant glioma cells?
D Aasland, T Reich, M Christmann, B Kaina · Klinische Pädiatrie · 2013 · Heft 11
Dokument
1051322
CareLit-ID
Jahr
2013
Publikation
PDF
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Metadaten
DOI
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Zusammenfassung
First-line chemotherapeutics for malignant gliomas are alkylating agents, which have methylating (temozolomide) and chloroethylating (BCNU, CCNU, ACNU, fotemustine) properties. These drugs induce a plethora of DNA adducts from which the minor adducts O6-methylguanine and O6-chloroethylguanine are the main toxic one. These DNA lesions are repaired by the suicide enzyme O6-methylguanine-DNA methyltransferase (MGMT), which transferes the alkyl group to an own cysteine residue, thereby restoring guanine in the DNA and thus preventing from cell death. MGMT is not expressed in 17% of primary glioblastomas on enzyme le…
Schlagworte
Alkylating Agents
Dexamethason
Cysteine
Work
ACNU
Klinische Pädiatrie
