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In vitro and ex vivo toxicity screening for predicting toxicological effects of synthetic carbon black nanoparticles in humans

T Hansen, J Kopf, O Danov, M Ströbele, A Braun, K Sewald, H Bockhorn, H Fehrenbach · Pneumologie · 2013 · Heft 12

Dokument
1051450
CareLit-ID
Jahr
2013
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
T Hansen, J Kopf, O Danov, M Ströbele, A Braun, K Sewald, H Bockhorn, H Fehrenbach
Ausgabe
Heft 12 / 2013
Seiten
–
Erschienen: 2013-12-09 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0033-1357065

Zusammenfassung

The aim of this study was to compare the effects of synthetic carbon black nanoparticles (CBNP) with and without polycyclic aromatic hydrocarbons adsorbed to their surface. Printex®90 and acetylene soot particles as well as particles covered with either benzo[a]pyrene (BaP) or nitroanthracene (NA) were tested in human pulmonary cell lines (16HBE14o-, Calu-3, A549) and precision cut lung slices (PCLS) of mice, rats and humans using a wide concentration range. Particle size distribution in the cell culture medium was determined by dynamic light scattering. Viability assays were LIVE/DEAD® staining and WST-1 assay…

Schlagworte

Acetylene After Cytokines Reactive Oxygen Species Benzo(a)pyrene Pneumologie