Differential expression of trophoblast-, endothelial- and embryonic-stem-cell-associated transcription factors in 1st trimester, and 3rd trimester preeclampsia (PE), intrauterine…

Stem cells are highly proliferative, undifferentiated cells and stem cell markers are involved in maintaining these characteristics. In the blastocyst, differential expression between embryonic and trophoblast stem cell transcription factors is thought to discriminate cell fate. Although villous cytotrophoblasts are functionally considered a trophoblast stem cell or at least a progenitor cell, which replenishes the outer syncytiotrophoblast layer when necessary, little data is available characterizing the expression of stem cell transcription factors beyond the blastocyst stage. We aimed to describe the expressi…