CareLit Fachartikel
A story about hepatic inflammatory and regenerative processes: An in vitro model of liver damage shows influence from hepatic tissue quality and donor anamnesis
V Kegel, E Pfeiffer, T Schulz, B Burkhardt, D Seehofer, A Nüssler, G Damm · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Dokument
1051798
CareLit-ID
Jahr
2014
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Hepatic tissue damage can occur due to several diseases like cholestasis, infections or liver tumors. Kupffer cells (KC) play an important role in mediating tissue damage as well as regenerative processes. KC activation by lipopolysaccharide (LPS), antigens or endogenous proteins such as released under necrotic conditions can lead to an activation of the NF-κB signaling pathway transmitted by reactive oxygen intermediates (ROI). Once activated, KC release different cytokine patterns that support inflammation or induce tolerance reactions. Aim of the present study was the establishment of a human in vitro model f…
Schlagworte
Cytokine
Cytokines
Lead
Cholestasis
Antigens
Zeitschrift für Gastroenterologie
