CareLit Fachartikel
Tauroursodeoxycholic acid exerts anti-apoptotic effects by a MKP-1- and PKA-dependent mechanism in rat liver
A Sommerfeld, R Reinehr, D Häussinger · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Dokument
1051808
CareLit-ID
Jahr
2014
Publikation
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Metadaten
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Zusammenfassung
Introduction: Ursodeoxycholic acid, which in vivo is converted to its taurine conjugate tauroursodeoxycholic acid (TUDC), is a mainstay for the treatment of cholestatic liver disease. TUDC is also effective in protecting hepatocytes for apoptosis induced by hydrophobic bile salts. The aim of the study was to elucidate the underlying signaling events. Methods: Rat livers were perfused with GCDC (20µmol/L) and TUDC (20µmol/L) for up to 120 min while cell culture experiments were performed in primary rat hepatocytes, which were stimulated with GCDC (50µmol/L) and TUDC (100µmol/L) for up to 360 min. Activation of ki…
Schlagworte
Apoptosis
Association
Antibodies
Caspase 3
3-Isobutyl-1-methylxanthin
After
Zeitschrift für Gastroenterologie
