Capsaicin impairs carcinogenesis of human intra- and extrahepatic cholangiocarcinoma cells
A Wutka, V Palagani, M El Khatib, H Belhamer, P Bozko, N Malek, R Plentz · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Cholangiocarcinoma (CC) is a cancer disease which is increasing worldwide. Capsaicin (N-vanillyl-8-methyl-1-nonenamide), the most abundant pungent molecule produced by pepper plants, represents an important ingredient in spicy foods consumed throughout the world. It is well reported that capsaicin has anti-proliferative effects on various human malignancies like leukemia esophageal carcinoma, gastric cancer, pancreatic cancer, colon carcinoma and breast cancer. The aim of the present study is to explore the anti-tumor activity of capsaicin in human CC cell lines. Methods: We analyzed the effect of…